Podcast

Invest Like the Best

Patrick O'Shaughnessy explores business, investing, and company building with founders, investors, and operators.

Invest Like the BestOct 6, 2026

Andrew Huberman - The Frontier of Neurotechnology - [Invest Like the Best, EP.494]

Andrew Huberman argues the next big frontier in neuroscience is not just reading the brain, but precisely writing to the nervous system in sleep and waking states. The episode spans sleep optimization, neuromodulation, AI-adjacent neurotech, and the ethics of genetic engineering, while ending on a career philosophy of following genuine curiosity.

Invest Like the BestSep 28, 2026

Noah Shinn - Building Instinct: The Personal Agent - [Invest Like the Best, EP.493]

Noah Shinn says Instinct is building a personal agent that users can text, call, or email, with a strong focus on trust, safety, and simple interfaces. The company is already seeing rapid invite-only growth, over $1B in annual transaction volume, and a business model built around take rates rather than ads or subscriptions.

Invest Like the BestSep 22, 2026

Gabe Stengel - Building Investing Superintelligence - [Invest Like the Best, EP.492]

Gabe Stengel argues that AI will remake finance through workflow automation, auditability, and better harnesses around frontier models, not just better models. Rogo is positioning itself as the operating layer for dealmakers and bankers, with a long-term bet that capital markets will become faster, more standardized, and more software-driven.

Invest Like the BestSep 16, 2026Michael Moritz

Michael Moritz - Lessons From 40 Years of Investing and Writing - [Invest Like the Best, EP.491]

Michael Moritz reflects on how his refugee family history shaped his identity, instincts, and lifelong sense of vigilance. He also covers Sequoia’s evolution, venture investing before the internet, leadership lessons from Alex Ferguson, his views on Elon Musk and AI, and why writing remains central to his life.

Invest Like the BestSep 8, 2026

Walter Russell Mead - How America Keeps Winning - [Invest Like the Best, EP.490]

Walter Russell Mead argues that American power is still strong even as the post-1945 system frays, and that Trump, tech competition, and global fragmentation are reshaping how power works. He also makes a detailed case that AI, drones, and information technology are changing war, deterrence, and the balance between the U.S., China, India, and Iran.

Invest Like the BestSep 1, 2026Sarah Guo

Sarah Guo - Funding the Frontier - [Invest Like the Best, EP.489]

Sarah Guo argues AI investing is unusually hard to backtest, with the biggest constraints now shifting from model quality to compute, power, regulation, and supply chains. She also makes a case for open source diffusion, robotics, and biology as major arenas where AI can create durable value.

Invest Like the BestAug 25, 2026Neil Movva

Neil Movva - Making AI 10x Cheaper - [Invest Like the Best, EP.488]

Neil Movva argues Sail is building a token factory for a world of long-running AI agents, where cost per token matters far more than latency. The episode goes deep on the full stack of AI infrastructure, from GPU batching and KV cache to heterogeneous chips, HBM shortages, power scavenging, and why cheaper intelligence could create entirely new product categories.

Invest Like the BestAug 18, 2026

Ben Thompson on Big Tech, China, and the AI Boom Running Out of Money - [Invest Like the Best, EP.487]

Ben Thompson argues the AI boom is as much a capital, power, and supply-chain story as a model-quality story. He is bullish on AI’s economic impact but warns that U.S.-China rivalry, hidden financing risk, and long infrastructure lead times could create a brutal shakeout before monetization catches up.

Invest Like the BestAug 11, 2026

Eric Vishria - A Decade of Lessons Investing in Software & Hardware - [Invest Like the Best, EP.486]

Eric Vishria argues that AI is following a cloud-like path toward oligopoly, but with even faster enterprise adoption and new bottlenecks in energy, compute, and product design. He also shares hard-won lessons from Cerebras, robotics, and AI-native go-to-market, emphasizing first-principles thinking and founder chemistry.

Invest Like the BestAug 4, 2026

Gavin Baker - AI Market Jitters - [Invest Like the Best, EP.485]

Gavin Baker argues the July selloff in AI stocks disconnected public-market prices from improving fundamentals, with GPU availability, rental pricing, token demand, and hyperscaler operating cash flow all moving higher. He says the biggest risk is regulation, while long-term compute demand could still be enormous if AI monetization, open-source dynamics, and new infrastructure financing models keep compounding.

Invest Like the BestJul 28, 2026

Sam Altman - How to Make an Abundant Future - [Invest Like the Best, EP.484]

Sam Altman argues OpenAI is refocusing around abundant, cost-effective intelligence, backed by massive compute, custom chips, and industrial-scale data centers. He also discusses robotics, ChatGPT’s origin, frontier model competition, AI security, and why he thinks the next few years will bring major product and capability shifts.

Invest Like the BestJul 21, 2026

Matthew Smith — Natural Gas: The Next Bottleneck - [Invest Like the Best, EP.483]

Matthew Smith argues the U.S. is heading into a natural gas supply crunch by 2028-2030 as AI data centers and LNG exports compete for a constrained system. He says the bottleneck is deliverability and infrastructure, not geology, and sees nuclear and residential solar as key long-term responses.

Invest Like the BestJul 14, 2026

John Kim - How to Raise a Few Billion Dollars - [Invest Like the Best, EP.482]

John Kim argues that fundraising is fundamentally about trust, not just persuasion or logic. He lays out a practical playbook for raising capital: start with high-trust backers, build consensus, differentiate clearly, and keep the story simple enough to repeat.

Invest Like the BestJul 7, 2026Jeremy Giffon

Jeremy Giffon - The Billion Dollar PDF - [Invest Like the Best, EP.481]

Jeremy Giffon argues that in private markets, narrative is often the real bottleneck: capital follows the best story, not just the best business. He also maps a broader shift in media, finance, and culture toward timeline-native institutions, algorithmic attention, and a new elite made of posters rather than billionaires.

Invest Like the BestJun 30, 2026Gavin Uberti, Rob Wachen

Etched - Building AI Hardware to Make Inference Faster and Cheaper - [Invest Like the Best, EP.480]

Etched is building a full inference stack, not just a chip, with a custom architecture optimized separately for prefill and decode. The founders argue that low-voltage operation, cluster-scale memory, and extreme vertical integration will make inference dramatically faster, cheaper, and eventually one of the largest markets in the world.

Invest Like the BestJun 23, 2026

Vlad Barbalat - Investing $120 Billion in Permanent Capital - [Invest Like the Best, EP.479]

Vlad Barbalat explains how Liberty Mutual Investments manages roughly $120 billion of permanent capital across insurance reserves and surplus, using a long-term, liquidity-aware framework rather than market forecasting. He also discusses branded capital, AI, geopolitics, and how his immigrant background shaped his views on risk, entrepreneurship, and continuous improvement.

Invest Like the BestJun 16, 2026

Kareem Amin - The Unusual Approach to Company Building - [Invest Like the Best, EP.478]

Kareem Amin explains how Clay grew by targeting creative go-to-market users with an unusually powerful, open-ended product and usage-based pricing. The conversation then broadens into his philosophy on courage, justice, self-respect, vision, meditation, and why not every company should be forced to scale forever.

Invest Like the BestJun 9, 2026

Alex Sacerdote - How to Invest Through Technology Cycles - [Invest Like the Best, EP.477]

Alex Sacerdote argues that AI is creating a new technology stack, with Anthropic emerging as his highest-conviction private investment because leading models, enterprise distribution, and coding use cases are starting to compound. He also lays out Whale Rock’s broader S-curve framework for investing in tech, then applies it to AI infrastructure, software disruption, and how his firm uses AI in research.